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Symbol
Name
ID

Tpp1
tripeptidyl peptidase I
MGI:1336194

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Dysphagia

Oculomotor apraxia

Cerebral atrophy

Cerebellar atrophy

Increased extraneuronal autofluorescent lipopigment

Increased neuronal autofluorescent lipopigment

Ataxia

Dysmetria

Gait ataxia

Limb ataxia

Clumsiness

Myoclonus

Postural tremor

Truncal titubation

Babinski sign

Abnormal nervous system electrophysiology

Delayed speech and language development

Dysarthria

Scanning speech

Hyperreflexia

Unsteady gait

Developmental regression

Seizure

Impaired vibratory sensation

Disease(s) Associated with TPP1

autosomal recessive spinocerebellar ataxia 7

neuronal ceroid lipofuscinosis 2

Mouse Phenotypes		seizures	audiogenic seizures	abnormal brain morphology	abnormal Purkinje cell morphology	Purkinje cell degeneration	neuronal cytoplasmic inclusions	neurodegeneration	demyelination
Availability	Mouse Genotype	seizures	audiogenic seizures	abnormal brain morphology	abnormal Purkinje cell morphology	Purkinje cell degeneration	neuronal cytoplasmic inclusions	neurodegeneration	demyelination
	Tpp1^m1J/Tpp1^m1J
	Tpp1^tm1.1Plob/Tpp1^tm1.1Plob
	Tpp1^tm1Dgen/Tpp1^tm1Dgen
	Tpp1^tm1Plob/Tpp1^tm1Plob
	Tpp1^tm1Plob/Tpp1^tm1.1Plob

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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